Carboxylic acids are ubiquitous in bioactive organic molecules and readily available chemical building blocks. Carboxylic ...

Some of the most common functional groups that are amenable to prodrug design include carboxylic, hydroxyl, amine, phosphate/phosphonate and carbonyl groups.

Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class ...

Rotation about the C−N bond in amides can be catalyzed by Brønsted and Lewis acids, as well as nucleophiles and bases. Catalysis of amide isomerization occurs in biological systems via “rotamase” ...