Fifty years ago, Bernard Katz's seminal work revealed that calcium triggers neurotransmitter release by stimulating ultrafast synaptic vesicle fusion. But how a presynaptic terminal achieves the ...

Brain ion channels have molecular memory, changing shape after repeated signals, affecting neurotransmitter release.

A new study conducted by researchers at the Max Planck Florida Institute for Neuroscience uncovers critical aspects of calcium channel ... variability in neurotransmitter release during neuronal ...

as a calcium store. This leads to elevated neurotransmitter release and, ultimately, to fatal neuronal hyperexcitability. These fundamentally new findings have now been published in the ...

Calcium channels play a central role in pain signaling, in part through the release of neurotransmitters such as glutamate and GABA -- "the currency of the pain signal," according to Rajesh Khanna ...

Calcium ions rapidly stream into the presynaptic ... with neurotransmitter to fuse with the plasma membrane and release the neurotransmitters into the synaptic cleft. Speed is essential in ...

A study conducted by researchers at the Max Planck Florida Institute for Neuroscience uncovers critical aspects of calcium channel ... variability in neurotransmitter release during neuronal ...

The work shows how inhibitory synapses are stabilized when the neurotransmitter glutamate ... to the mGluR receptor and leads to the release of calcium from internal storage into the neuron's ...

The team then used imaging techniques to measure acetylcholine levels and calcium influx. Calcium is essential for neurotransmitter release. In the eIF4E mice, acetylcholine binding to dopamine axons ...

Under normal conditions, brain tissue is sufficiently supplied with energy, which is in part required for the selective release and reuptake of neurotransmitters. "However, if there is no longer ...