Figure 2: Role of insulin/IGF-1 and TGF-β pathways in controlling reproductive growth versus dauer development ... Figure 5: Structures of the C. elegans acyl-CoA oxidases ACOX-1.1 and ACOX ...

"Our evidence suggests that DAF-36 works early in a pathway ... the C. elegans reproductive capacity and prevent the organism from going into the immature long-lived larval phase called dauer ...

Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The increase in lifespan ...

The paper C.Y. Ewald et al., “Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity,” Nature, doi:10.1038/nature14021, 2014. The ...

This worm, the C. elegans, is often used in aging research. Even though it’s biologically a long way from humans, it shares many genetic pathways with humans. “Nature doesn't waste basic cell ...

By comparison, restoration of DAF-2 or AGE-1 in muscle regulated metabolism but did not reverse the dauer stage or lifespan ... essential functions in C. elegans, and the metabolic and ...

Past research had found a link between two signaling pathways in C. elegans — the insulin signaling pathway and the target of rapamycin pathway — and aging. Specifically, scientists found that ...

In experiments with roundworms of the species Caenorhabditis elegans, researchers at the State University of Campinas (UNICAMP) in Brazil found that when this communication pathway is dysregulated ...

The study, “Parallel Pathways for Serotonin Biosynthesis and Metabolism in C. elegans,” challenges the existing knowledge of how serotonin is produced and what happens to the neurotransmitter ...

New study has identified synergistic cellular pathways for longevity that increase the life cycle five times in C. elegans, nematode worm is used as a model in adult research. The discovery of ...

and Nanjing University in China, have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The ...