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Blood samples were collected pretest and up to 24 h post-test to assess pharmacokinetics (PK), pharmacodynamics (PD), and C-peptide levels. Conclusion: The different extent of inhibition of endogenous ...

(22) Little is known about RufO’s catalysis, including the substrate recognition mechanism, the changes at the catalytic site and overall protein structure in response to peptide binding, the ...

Hence, UV-exchanged tetramers have been developed to upscale this, however, still has some associated challenges such as UV-mediated damage to peptide complexes. Here, Pothast, C.R. et al demonstrate ...

Here we present data that this peptide-exchange technology is a general applicable, ready-to-use and fast approach to load many different peptides in MHC-I multimers for alleles of the HLA-A, HLA-B ...

Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising. In particular, peptide ...

focusing on glucagon-like peptide-1—GLP-1—receptors. Using the probe to target these receptors—expressed in abundance on insulinoma cells—they conducted a Phase II clinical trial ...

A hormone-producing tumor originating in the pancreas -- an insulinoma-- is the cause. Patients with the condition often experience severe hypoglycemia, resulting in convulsions, impaired ...