This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

Scientists have mapped how over 140,000 mutations affect the formation of amyloid beta fibrils, offering an unprecedented look at early events in Alzheimer’s disease.

"The scale at which we analyzed the amyloid peptides was unprecedented," said Ben Lehner of the Wellcome Sanger Institute.

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates ...

By analyzing thousands of Aβ42 peptides, the scientists gained a better understanding of how mutations in Aβ affect protein ...

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates ...

NHC Key Laboratory of Birth Defect Research and Prevention, MOE Key Laboratory of Rare Pediatric Diseases, Institute of Cytology and Genetics of School of Basic Medical Sciences & Department of ...

In both contexts, phosphorylation at the C-terminal domain alters the behavior of SAS-6, affecting its phase separation in vitro and cartwheel assembly in vivo. While these processes exhibit distinct ...