Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis ... of the HIF pathway were awarded the Nobel Prize in Physiology or Medicine in 2019.

Background There is little consensus regarding the use of echocardiography in patent ductus arteriosus (PDA) treatment in preterm infants. The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) ...

Genome-wide association studies have identified that NPR-C (natriuretic peptide receptor-C ... Ang II dose and time-dependently upregulated WNK4/SPAK/NCC kinase pathway and NPR-C/Gi/PLC/PKC signaling ...

Infigratinib joins the field of potential achondroplasia therapies with the transiently pegylated C-natriuretic peptide (CNP), navepegritide (TransCon CNP, Ascendis Pharma), in phase 3 clinical ...

NPR-C is the most abundant class of NPR, comprising >95% of the total NPR population, and is thus the dominant mode of natriuretic peptide clearance.6 An alternative metabolic pathway for natriuretic ...

This study presents valuable findings on the impact of C-natriuretic peptide (CNP) treatment in vivo on the fertility of aged mice. Solid data indicate CNP induces the cAMP-PKA pathway, causing ...

In conclusion, goat mammary gland expressed NPR-B, indicating mammary gland was the target organ for natriuretic peptide system. Moreover, CNP, through NPR-B/JNK/c-Jun signaling pathway to regulate ...

Evidence suggests that the natriuretic peptide clearance receptor (NPR-C) pathway may play a role in the development and pathobiology of obesity-related HFpEF. Therefore, therapeutic manipulations of ...

Brain natriuretic peptide (BNP ... components of the BNP signalling pathway were evaluated after BNP injections in unmanipulated or infarcted mice (Figure 1). BNP binding to the receptors NPR-A and ...

pathway to counteract FGFR3 overactivation and restore chondrogenesis. The most advanced candidates are 17–amino acid cyclic disulfide peptide analogs of C-type natriuretic peptide (CNP)—vosoritide ...