We found that 93 protein-coding cancer genes carried probable driver ... understanding of the origins and consequences of somatic mutations in breast cancer. Figure 3: Extraction and contributions ...

Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe ...

Recent research and genomic studies have revealed a number of genes that accumulate somatic, or non-inherited, mutations and alterations in estrogen receptor positive (ER+) breast cancer.

Oncotarget published "Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients" which reported that the association between genetic ...

Breast cancer can run in families ... to cancer are acquired during your lifetime. These are called somatic mutations. Somatic mutations happen due to things like the natural aging process ...

“Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].” Somatic HER2 mutations are a novel class ...

are a small subset of somatic mutations that drive the development of cancer. Dr Patrick Tarpey, first author from the Wellcome Trust Sanger Institute, said: “Breast cancer is the most common cancer ...

Dr. Mabel Mardones educates patients on breast cancer subtypes, as well as treatment options for those with ER-positive, HER2 ...

A small proportion of women who receive anti-estrogen treatment after breast cancer surgery have worse outcomes. This is associated with mutations in the estrogen receptor gene, according to a ...

BRCAness refers to tumors that mimic BRCA1/2 mutation behavior, making them vulnerable to DNA-damaging treatments like PARP ...

A new editorial paper was published in Oncotarget's Volume 14 on October 31, 2023, entitled, "The uncharted role of HER2 mutant alleles in breast cancer." Somatic HER2 mutations are a novel class ...