In T cells, Blimp-1 enhances IL-4 and IL-10 production and may enhance activation-induced cell death (AICD), in vivo T reg cell function and survival of double-positive (DP) thymocytes.

They also discovered that CD4 T-cells can be regulated by Blimp-1 protein expression. Through regulating CD4 T-cells, CD8 T-cells can be regulated, which could lead to new therapeutic possibilities.

They also discovered that CD4 T-cells can be regulated by Blimp-1 protein expression. Through regulating CD4 T-cells, CD8 T-cells can be regulated, which could lead to new therapeutic possibilities.

BLIMP-1 binds to a site in MHC2TA promoter III. Previous evidence has suggested that CIITA is down-regulated in plasma cells at the level of transcription by a cell type–specific factor 24,26,40 ...

CAR T-cell therapy that targets BCMA is an effective option for treating relapsed/refractory multiple myeloma, but there is a lack of persistence due to the inability to develop a memory phenotype. ..

Two recent studies have connected protein Blimp1 to key regulation of plasma cells’ ability to produce pathogen-fighting antibodies. Without this protein, scientists estimate numerous cases of cancer ...

Researchers conducted a phase 1 randomized clinical trial across clinical research centers in Uganda, Kenya, and Zambia to evaluate the safety and immunogenicity of the HIVconsvX T-cell vaccine ...