He made a conceptual leap in immunotherapy by creating a hybrid T-cell, known as CAR-T, that was genetically modified to ...

The Offspring briefly interrupted their set to acknowledge Osbourne, the Black Sabbath frontman who died earlier Tuesday. The band, including bassist Todd Morse, drummer Brandon Pertzborn and ...

An international team of researchers has made a key discovery: many children and young adults in Sub-Saharan Africa diagnosed with type 1 diabetes (T1D) may have a different form of the disease—one ...

In a recent landmark study, scientists have unveiled how HIV-1 penetrates the cell's nuclear barrier—a discovery that could reshape antiviral strategies. The research, led by Professor Peijun Zhang, ...

FDA updates CAR T-cell therapy labels, easing monitoring requirements and expanding access for eligible patients in oncology.

Novel T-cell immunotherapies (chimeric antigen receptor [CAR] T cells and T-cell redirecting bispecific antibodies) are changing the treatment landscape of relapsed or refractory multiple myeloma. In ...

Discover how zimislecel enables insulin independence in patients with Type 1 diabetes, showing strong efficacy in early clinical data.

Current approved CAR T-cell therapy treatments rely on an ex vivo route, in which a patient’s T cells are removed, genetically engineered to target antigens, and put back into the patient. From ...

Using CD34 lineage-tracing mice and single-cell RNA sequencing, we identified a Tfh cell population derived from CD34-lineage CD4 + T cells. Untargeted and targeted metabolomics revealed distinct ...