Proteins enter this compartment as extended polypeptides and fold into their functional state in a process that is assisted by lumenal chaperones such as BiP. The protein folding machinery of the ...

Additionally, recombinant BiP, an ER-resident chaperone ... More information: Claudio Hetz et al, Essential roles of the unfolded protein response in intestinal physiology, eGastroenterology ...

Nat Struct Mol Biol 2018; 25(1): 90–100. 20. Chung KT, Shen Y and Hendershot LM. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. J ...

BiP binding seems to be directly proportional ... which serves to tag misfolded protein for degradation by a proteasome-mediated pathway. A similar dependence on mannosidase I activity was ...