Plants produce an astonishing variety of chemical substances. Most of these metabolites are involved in chemical ...

Further investigations revealed that the biosynthetic pathways of these complex chemical compounds have developed independently in the two species. ... saponins or monoterpenoid indole alkaloids.

The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently Plants produce an enormous ...

A significant subset of the so-called prenylated indole alkaloids (PIAs) contains an angularly fused pyrano[2,3-g]indole core, while a smaller number embody the isomeric and linearly fused ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway.In this phase 3, double-bli ...

Background: The advent of immune checkpoint inhibitors (ICIs) targeting the PD-1 pathway, including nivolumab, pembrolizumab, and atezolizumab, has significantly improved the efficacy outcomes, namely ...

Inspired by nature’s biosynthesis of indole alkaloids, Chang and Toste’s team developed an N-sulfonyl oxaziridine reagent that reacts selectively and quickly with tryptophan residues that are ...

The paper concludes that "blockade of indole generation may present a unique therapeutic pathway" for rheumatoid arthritis and spondyloarthritis. That's all about finding the right path for the ...

Further, by identifying two demethylases Cc6DM2 and Cc6DM3, the biosynthetic pathway of jatrorrhizine was finally resolved after years of debate and search for biosynthetic enzymes that could ...

Plants are impressive in their diversity, but especially in the variety of metabolites they produce. Many plant natural products are highly complex molecules, such as the alkaloids vincristine and ...

Reference: Chavez B et al. Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform. PNAS. 2022. doi: 10.1073/pnas.2215372119. This article has ...