RGD peptides have been incorporated into several gene delivery vehicles to enhance specific interactions of nonviral vehicles with the cell surface. However, there are contradictory results regarding ...

Figure 1. K + competitively inhibits Na + -mediated [3 H]leucine binding in LeuT. (A) Na + -mediated [3 H]leucine (10x Kd) binding to purified LeuT in the absence (red triangles) or presence of 200 mM ...

Current models of motor coupling invoke either direct mechanical linkage or protein crowding, which rely on short-range motor-motor interactions. In contrast, coupling mechanisms that act at longer ...

Yet there is no percentage in picking upsets on the 2/15 or 3/14 bracket couplings. Over the past five NCAA tourneys, No. 2s are 18-2 vs. No. 15s and No. 3s are 18-2 vs. No. 14s.

Yet there is no percentage in picking upsets on the 2/15 or 3/14 bracket couplings. Over the past five NCAA tourneys, No. 2s are 18-2 vs. No. 15s and No. 3s are 18-2 vs. No. 14s.

Yet there is no percentage in picking upsets on the 2/15 or 3/14 bracket couplings. Over the past five NCAA tourneys, No. 2s are 18-2 vs. No. 15s and No. 3s are 18-2 vs. No. 14s.

The structures of the receptors marked with red dots have already been solved experimentally (Kooistra et al., 2021). GPCRs have multiple ligand binding sites, the orthosteric binding pocket and a ...

Excitatory amino acid transporters (EAATs) maintain glutamate gradients in the brain essential for neurotransmission and to prevent neuronal death. They use ionic gradients as energy source and ...

Proteins transduce information and signals within the human body by changes in their structures. For example, hormones binding to their target proteins cause a structural change which in turn opens ...

Researchers refer to this coupling of different, distant binding sites as allostery. An interruption of this coupling leads to signals not being passed on.