Resumption of dosing in this study triggers a $10M milestone payment from GSK plus an additional $20M milestone due in six months; as previously disclosed GSK disputes these milestone payments, and ...

In this project we investigate by means of high-level QM/MM-methodology, the mechanism of action of carbapenemases, and in particular KPC-2, towards representative compounds from the different classes ...

Genomic sequencing identifies novel drug targets and resistance mechanisms ... Beta Lactam antibiotics work by inhibiting the bacterial enzymes responsible for cell wall synthesis, while Beta ...

Jawa International has created over 700 jobs with the launch of Beta Lactam Pharmaceutical Manufacturing Facility ... “This is the tangible impact of industrialization in action—job creation, retained ...

Penicillin belongs to the beta-lactam family of antibiotics, the members of which use a similar mechanism of action to inhibit bacterial cell growth that eventually kills the bacteria. Bacteria ...

Noah M. Merin, MD, PhD, assistant professor at Cedars-Sinai Medicine and medical director of the Hematology and Cellular Therapy Disease Research Group at the Cedars-Sinai Cancer Institute, discusses ...

ABSTRACT: The increase and spread of bacterial resistance to extended-spectrum beta-lactam antibiotics are reported in many infections and are a real public health problem worldwide. Drug pressure is ...

In this paper such natural small molecules and its molecular mechanisms are considered. The developed drug delivery systems for tafamidis and diflunisal based on biosafe as well as biodegradable ...