While most pharma companies have exited the antibiotics area, Japanese drugmaker Shionogi has stuck with it and has just expanded its pipeline with a deal to buy US biotech Qpex Biopharma.

BLIs are designed to overcome a key resistance mechanism that allows pathogens to protect themselves from cefepime and other antibiotics in the beta-lactam class and have been used to restore acti ...

There are many different types of antimicrobials, each with distinct mechanisms for targeting pathogens and other disease-causing organisms. For example, β-lactam antibiotics such ... to determine the ...

The following is a summary of “Impact of aminoglycosides on survival rate and renal outcomes in patients with urosepsis: a ...

“This elucidation of MIPLYFFA’s ® highly differentiated mechanism of action marks a critical step in understanding its interactions with Niemann-Pick disease type C (NPC) at a cellular level ...

Zevra Therapeutics, Inc. announced the publication of a study on arimoclomol, branded as MIPLYFFA, in the journal Molecular Genetics and Metabolism, highlighting its unique mechanism of action in ...

Alnylam and BridgeBio are competing for people who are switching from Pfizer’s blockbuster ATTR amyloidosis drug tafamidis while all three companies are fighting for new patients.

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Their mechanisms of action are still poorly understood. However, the data in the literature indicate that silymarin and silibinin act in four different ways: (i) as antioxidants, scavengers and ...

particular care must be administered to the pregnant patient (clinical practice for those with mild to moderate pneumonia can reasonably include beta-lactam antibiotics -- ie, amoxicillin ...