The first type of penicillin resistance occurred when bacteria acquired an enzyme, known as a beta-lactamase, which destroys penicillin. To overcome this, drug manufacturers developed new ...

This kills the bacteria. Some bacteria produce beta-lactamase, an enzyme that can damage penicillin and block its effects. To stop this from happening, penicillins may be combined with substances ...

Zaynich is based on cefepime, a well-established beta-lactam antibiotic, combined with a novel beta-lactamase inhibitor ...

These advancements contribute to the discovery of improved beta lactam antibiotics and beta lactamase inhibitors, addressing antimicrobial resistance and infectious diseases.

Extended-spectrum beta-lactamases (ESBLs) are enzymes or chemicals produced by germs like certain bacteria. These enzymes make bacterial infections harder to treat with antibiotics. Here's what ...

Among children treated with an oral agent, the recurrence rate was 16/42 (38.1%) following penicillin or amoxicillin and 10/36 (27.8%) following a beta-lactamase resistant agent (adjusted odds ...

Beta-lactamase inhibitors restore or potentiate the activity of beta-lactam antibiotics. The combination of OP0595 with a beta-lactam antibiotic targets severe infections caused by ...

Dublin, April 03, 2023 (GLOBE NEWSWIRE) -- The "Global Antibiotics Market (2023-2028) by Action Mechanism, Drug Class, Spectrum, and Geography, Competitive Analysis, Impact of Covid-19 with Ansoff ...

We study known drug targets and also aim to discover new Achilles' heel opportunities: the main targets are proteins involved in peptidoglycan metabolism including penicillin-binding proteins (PBPs), ...