An experimental design was applied to improve the reaction conditions for enzymatic synthesis of ampicillin from phenylglycine methyl ester (PGME) and 6-aminopenicillanic acid (6-APA), catalyzed by ...

Penicillins and cephalosporins are beta-lactam antibiotics used to treat a wide range of bacterial infections. The drugs are structurally similar to each other and have the potential to cause a ...

However, cefazolin, which is used widely in hospitalized patients and for surgical prophylaxis, has a unique R1 side chain and is not like penicillin, so the risk of cross-reactivity is extremely low.

The following is a summary of “Discrepancies in Beta-Lactam Antibiotics Cross-Reactivity: Implications for Clinical Practice,” published in the February 2025 issue of European Journal of Allergy and ...

Patients who experienced allergic reactions after the beta-lactam challenge had them within 72 hours of admission, with four (2.2%) having reactions in an inpatient setting and one (0.5%) in the ED.

Drug hypersensitivity reaction (DHR) to NSAIDs was excluded by oral provocation tests with celecoxib and acetylsalicylic acid. Due to the unclear history of β-lactam allergy, after negative skin test ...

Risk Statement: The potential cross contamination with a non-antibacterial beta-lactam drug substance could lead to hypersensitivity reactions such as swelling, rash, urticaria and anaphylaxis, a ...

This could lead to reactions such as swelling, rash, urticaria and anaphylaxis. To date, Scynexis has not received any reports of adverse events because of possible beta-lactam cross contamination.

Risk Statement: The potential cross contamination with a non-antibacterial beta-lactam drug substance could lead to hypersensitivity reactions such as swelling, rash, urticaria and anaphylaxis, a ...