As Aurora-A kinase controls mitosis by regulating cyclin B localization/stability 39, 40 and bipolar spindle assembly, 38 we checked for mitotic abnormalities upon USP7 depletion.

We show that the mitotic kinase Aurora-A directly interacts with and phosphorylates RASSF1 and that RASSF1A is phosphorylated by Aurora-A during mitosis.

Aurora kinases, a group of serine/threonine protein family, comprise Aurora A, B and C members and are involved in the regulation of cell division and mitosis. Aurora A overexpression correlates with ...

Experts in mitosis (cell division) have made discoveries that explain how one protein -- the kinase Aurora B -- could have such a large role in guiding and policing the process of cell division.

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they ...

Alisertib is a highly selective small molecule inhibitor of Aurora A kinase which may result in disruption of the assembly of the mitotic spindle apparatus and cell proliferation inhibition. At ...

Puma Biotechnology Announces Exclusive License Agreement with Takeda for the Development and Commercialization of Alisertib, an Investigational Aurora Kinase A Inhibitor September 20, 2022 04:05 ...

Background: Malignant mesothelioma (MM) is an aggressive neoplasm of the serosal cavities, resistant to conventional treatment, for which new therapeutic targets are being actively sought. Aurora ...

Nurix Therapeutics Showcases Promising Preclinical Data for BTK, BRAF, and Aurora A Kinase Degraders at AACR 2025 Annual Meeting April 25, 2025 — 01:12 pm EDT.

Ellipses Pharma Presents Preliminary Data From the First in Human Phase-1/2 Trial of EP0042, a Dual FLT-3 and Aurora Kinase Inhibitor, at ASH.

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of the Journal of Cell Biology.