In relapsing-remitting multiple sclerosis, activation of the peripheral immune system can lead to focal inflammation within the CNS. Over the past three decades, therapeutic development has been ...

Targeted Oncology connects oncology professionals with updates on immunotherapy, biomarkers, cancer pathways, and targeted ...

A new technology that uses clinical MRI machines to image metabolic activity in the brain could give researchers and clinicians unique insight into brain function and disease, researchers at the ...

Our results suggest cotargeting of Aurora kinase B and SUV4-20H1/2 could be effective against p53-mutated or -deficient cancers, including triple-negative breast cancers in which approximately 80% of ...

Tiny brain tumors often hide in plain sight—sometimes no bigger than a grain of rice. These metastases, or secondary cancers that spread from other parts of the body, are especially dangerous.

Background: Existing research on the development of prognostic models for renal cell carcinoma (RCC) patients with brain metastases (BM) remains limited. This study aimed to develop a prognostic ...

Here, we investigated the antiviral effect of EA and UA against HSV-1 infection, a virus that causes peripheral infection as well as brain inflammation. Both compounds demonstrated potent antiviral ...

It has also been hypothesized that BMs may lie dormant behind the blood–brain barrier (BBB), where they can shelter from chemotherapeutic agents that control disease in less protected organs ...

Evopoint Biosciences Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an Aurora kinase A (AURKA; ARK1)-targeting moiety ...