that disrupts its kinase activity failed to fully activate YAP activity in the reporter system (Figure 3g). These results suggest that Aurora A signaling can positively regulate YAP-directed gene ...

PHILADELPHIA – In preclinical models, combining an investigational Aurora Kinase A (AURKA ... protein downstream of KRAS that amplifies RAS signaling and is also involved in regulating cell ...

About Aurora A Kinase Aurora A kinase (AURKA ... includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

Aurora Kinase Inhibitors and Cancer Cancer continues ... Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms.

Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, although the clinical development of Aurora kinase inhibitors has been so far ...

a dual specificity protein kinase, has emerged as a master regulator of mitosis and an upstream component of spindle checkpoint signaling pathway (Liu and Winey 2012). Our previous work led to ...

KiNet's interactive approach to visualizing kinase interactions can assist researchers in identifying novel drug targets and understanding the effects of potential treatments on complex signaling ...