Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

About Aurora A Kinase Aurora A kinase (AURKA ... includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene ...

Here, we demonstrate that inhibition of Aurora kinase A (AurA) dampens trained immunity induced ... Mechanistically, AurA inhibition reduced the activation of mTOR signaling, thus leading to the ...

Two signaling networks were identified downstream of PKA: RAS/MAPK components and an Aurora Kinase A (AURKA)/glycogen synthase kinase (GSK3) sub-network with activity toward MYC oncoproteins. Findings ...

Journal of Hematology & Oncology, 13, 155. 2 Abstract 2768 EP0042, a dual FLT3 and aurora kinase inhibitor: preliminary results of an ongoing phase 1/2a First in Human (FIH) study in patients with ...

Antibodies against the following proteins were used for immunoblotting: APPL1 (Cell Signaling Technology Cat# 3858, RRID:AB_2056989), p-Aurora kinases (Thr288 in ... For in vitro kinase assay, HEK293T ...

They identified and tested aurora kinase inhibitors ... studies should examine opportunities to similarly intervene in signaling by immune cells or other cells in the surrounding tumor stroma ...

Here, we investigated the effect of tozasertib, a pan-Aurora kinase inhibitor, on nerve injury-induced evoked and chronic ongoing pain in rats and the involvement of kinesin family member 17 (KIF17) ...

The authors have declared no conflicts of interest. Radiotherapy is one of the most conventional modes of treatment in several cancers. Failure of radiotherapy followed by acquisition of ...

In preclinical models, combining an investigational Aurora Kinase A (AURKA ... resistance can develop rapidly through adaptive signaling mechanisms that lead to reactivation of mutant KRAS ...

PHILADELPHIA – In preclinical models, combining an investigational Aurora Kinase A (AURKA ... protein downstream of KRAS that amplifies RAS signaling and is also involved in regulating cell ...