Three different classes of aurora kinases, A, B and C, have been identified, 1 each of which is involved in different mechanisms and aspects of cell signaling and mitotic division. 2 Aurora-A ...

Aurora A kinase activity influences calcium signaling in kidney cells. Journal of Cell Biology , 2011; 193: 1021-1032 DOI: 10.1083/jcb.201012061 Cite This Page : ...

In preclinical models, combining an investigational Aurora Kinase A ... resistance can develop rapidly through adaptive signaling mechanisms that lead to reactivation of mutant KRAS,” Lee noted.

In preclinical models, combining an investigational Aurora Kinase A (AURKA) inhibitor with a KRAS inhibitor or a WEE1 inhibitor showed efficacy against lung cancer cells with intrinsic or acquired ...

Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Nature Communications , 2022; 13 (1) DOI: 10.1038 ...

TPS2609 Background: Signaling hyperactivation secondary to MAPK pathway aberrations are common. ... STM-01: Phase I EFFTox study of aurora A kinase inhibitor alisertib (MLN8237) given in combination ...

Many cancers involve upregulation of Aurora kinase B, which helps deregulate normal cell cycling to drive tumor proliferation. The kinase should therefore be a good therapeutic target, yet no ...

Ellipses Pharma Presents Preliminary Data From the First in Human Phase-1/2 Trial of EP0042, a Dual FLT-3 and Aurora Kinase Inhibitor, at ASH.

Background: Malignant mesothelioma (MM) is an aggressive neoplasm of the serosal cavities, resistant to conventional treatment, for which new therapeutic targets are being actively sought. Aurora ...

In preclinical studies, ENMD-981693 has been shown to inhibit a unique profile of angiogenic tyrosine kinase targets in addition to the Aurora kinases. angiogenesis inhibitor, ENMD-981693.