Introduction Clostridioides difficile infection (CDI), the leading cause of hospital-acquired diarrhoea, is primarily driven by two potent toxins, TcdA and TcdB. However, the molecular mechanisms ...

Recent studies uncovered an important role of aquaporins in cell migration, and migration-associated cell function such as angiogenesis, wound healing, and neutrophil motility. Here we provide ...

Coconut water is hydrating and contains nutrients that can benefit regularity. However, it should be consumed in moderation ...

Brain swelling, or cerebral edema, is a medical emergency. Learn about the evidence-based treatments doctors use to reduce ...

The ocular lens microcirculation system (MCS) is required to maintain transparency; however, how this system is established and maintained as a function of age is not well understood. Through its role ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for ...

Landmark research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some promising cancer treatments are causing serious side effects, and offers ...

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

A new review from Genes and Diseases sheds light on the pivotal role of LINE-1 elements in preimplantation development and totipotency, revealing their essential contributions to early mammalian ...

Gene editing could be used to treat millions of glaucoma patients. Glaucoma is a leading cause of blindness, characterized by high pressure inside the eye. Patients often rely on daily eye drops ...