The study of antipsychotic receptor binding is relatively new and still evolving. Although the specific receptor-binding profile of various atypical agents is increasingly well understood ...

Distinct pharmacologic profiles, especially actions on 5-hydroxytryptamine (5-HT) receptor subtypes, may contribute to the advantage of atypical antipsychotics in terms of adverse effects.

“This is a landmark finding that completely revises our understanding of the neural basis for psychosis and charts ... D2 receptors. Dopamine is a key for both receptors, but antipsychotics ...

To conduct the study, the researchers matched information from a large national database of insurance claims to what is known about the receptor binding profiles of the antipsychotic drugs.

In a statement, John Krystal, MD, editor of Biological Psychiatry, who was not involved in the research, said antipsychotics have "a wide range of receptor profiles. The stroke risk profiles from ...

Now, scientists have solved the first high-resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug risperidone, yielding a long-awaited tool for drug ...

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic ... differences in drug-receptor interactions and ...

Karuna Therapeutics focuses on developing therapies that target muscarinic cholinergic receptors ... clinical profile compared to first and second-generation antipsychotics that have been used ...

Treatment with the investigational agent SEP-363856, a trace amine-associated receptor 1 (TAAR1 ... different adverse event profile compared with atypical antipsychotics, and is the "first ...

Now, scientists at the UNC School of Medicine and UC San Francisco (UCSF) have solved the first high-resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug ...