IN the early 1950's a team of chemists directed by George Hitchings undertook a new approach to the design and synthesis of antimetabolites that might inhibit neoplastic growth. Working from what w ...

Antimetabolites are a type of chemotherapy drug that mimics molecules that cancer cells need to create their DNA. Learn more about this cancer treatment.

The first attempts to control autoimmune disease by other than surgical therapy included the use of chemicals, such as urethane and nitrogen mustard, that had been demonstrated to suppress immunity ...

High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: ...

THE adaptation of micro-organisms1 and insects2 to antimetabolites used in the control of the latter is an important contemporary problem. It has been conjectured that a possible mechanism for ...