In an Editorial in July 2023, we wrote with optimism about the antifungal clinical development pipeline. At the time, several ...

Two bioactive ingredients in cannabis have been found to have antifungal properties when applied topically, according to a ...

However, scientists have now become increasingly aware that antifungal pesticides and antifungal drugs share some of the same mechanisms. The authors therefore warned that the promulgation of ...

Engineers at Brown University have designed a nanoscale drug delivery system that enhances the effectiveness of an antifungal drug against Candida species, including drug-resistant strains such as ...

The fungus can also invade the sinuses and spread to the brain, with a mortality rate around 50%. It causes tissue to die - cutting off blood flow so antifungal drugs can’t reach the infection site.

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

eLife Assessment. This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful ...

An example of this is an antifungal drug class called the azoles. ... Over the last 25 years, a compound with a novel mechanism of action has been in development called olorofim.

After F2G’s first attempt to get a brand-new class of antifungal to market was derailed by the FDA, the U.K.-based biotech has secured $100 million in fresh funding to bankroll another push ...