Tricyclic antidepressants (TCAs) were among the first drugs developed to treat depression. They’ve been on the market since the 1950s. TCA mechanism of action ...

Researchers have reported progress in the important effort to explain the rapid antidepressant action of ketamine, and in so doing, have gained insights that may inform the development of other ...

While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use.

The correlation between serotonin and depression is highly debated and is relevant for diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a ...

Yet their mechanisms of action—and their wider effects across the body—are still ... we are excited to explore whether antidepressants may help deliver drugs into other hard-to-reach corners ...

Saffron shows promise as a natural treatment for depression and cognitive decline, performing as well as standard drugs in ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

Auvelity, from Axsome Therapeutics, marks the first drug with a different mechanism of action approved for treating depression in 60 years. In clinical trials, participants reported… ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

Imipramine HCl 10mg, 25mg, 50mg. The exact mechanism of action is not known. However, it does not act primarily by stimulation of the central nervous system. The clinical effect is hypothesized as ...

Although the precise mechanism that ketamine uses to reduce depression symptoms isn’t fully understood, the drug has been shown to have remarkably fast and powerful antidepressant effects in ...

Auvelity is a new, fast-acting drug used to treat major depressive disorder or clinical depression. It is the first pill in more than 60 years with a new action to treat the condition.