Prozac®, the trade name for the drug fluoxetine, was introduced to the U.S. market for the treatment of depression in 1988. Thirty years later, scientists still don't know exactly how the ...

These mechanisms of ketamine action are not mutually exclusive and may act complementary in exerting the antidepressant actions of the drug as all hypotheses propose acute changes in synaptic ...

Lisa M. Monteggia, Ph.D., and Ege T. Kavalali, Ph.D., senior faculty at Vanderbilt University's School of Medicine, have been trying to reverse-engineer ketamine's mechanism of action for several ...

New drugs to treat depression in particular are needed because many existing antidepressants don't work in up to 50% of ... The mechanism of action of the study drug provides insights into the ...

The mechanism directly links antidepressant activity to neuronal plasticity and may account for the slow onset of action of typical antidepressants. ... [TMD] of TRKB," said Castren. Several targets ...

Intracellular mechanisms of antidepressant drug action. Harv Rev Psychiatry 2000; 8: 161–174. Article CAS PubMed Google Scholar Sun MK, Alkon DL . Protein kinase C substrate ...

While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use.

Scientists have identified a novel mode of action for a potential antidepressant that also leads to nerve cell growth in the mouse hippocampus. The activator of a serotonin receptor uses a ...

A new study has uncovered a new mechanism that helps explain the rapid, and long-lasting, antidepressant effects of controversial drug ketamine. The research reveals the drug operates in a way ...

Although the specific mechanisms of action responsible for the acute antidepressant effects of ketamine have yet to be determined, it has generally been thought that they are caused by the drug's ...

“Thank goodness we now have something with a different mechanism of action than previous ... a foothold in the $12 billion global antidepressant market, where most drugs now are ...

Researchers have reported progress in the important effort to explain the rapid antidepressant action of ketamine, and in so doing, have gained insights that may inform the development of other ...