Antibodies are a major component of adaptive immunity against invading pathogens. In this presentation, we will describe an analytical approach to characterize the antigen-specific antibody repertoire ...

The method utilises a “structure-to-sequence” computer algorithm ... used high-resolution cryo-EM to rapidly and precisely map where antibodies in rhesus macaque monkeys bind to synthetic ...

The protein one is seeking an antibody to is screened against this random sequence array and peptides ... desired protein for binding affinity and a map is produced displaying this affinity ...

In a study published in Nature Communications in August, for example, the researchers used high-resolution cryo-EM to rapidly and precisely map where antibodies ... a “structure-to-sequence” computer ...

Researchers show that analyzing the 3D shapes of antibodies, not just their genetic sequences, can better group functionally ...

The ability to obtain antibody RNA sequences and map these sequences back to the single B cells from which they came was not only higher-throughput than previous approaches; it also allowed them to ...

However, this approach is not as successful in helping predict the structure of antibodies, since unlike most other protein sequences, antibodies are extremely variable. “The body makes billions ...

An antibody comprising an amino acid sequence having at least a 90% sequence identity to SEQ ID NO:1. The antibody of claim 1, wherein the amino acid sequence comprises the sequence of SEQ ID NO ...