The study is published in the journal PLOS Pathogens. With only seven genes, the BK polyomavirus must use the host cell’s DNA replication machinery to produce new viruses. Although the virus was ...

Viruses are a mysterious and poorly understood ... We wondered whether protein language models could answer this question: “Given all annotated viral genetic sequences, what is this new sequence ...

A new study looking at the replication stage of the SARS-CoV-2 virus that causes COVID-19 reveals important mechanisms in its replication that could be the foundation for new antiviral therapies.

The enzyme methyltransferase MTr1 provides the cap structure of cellular RNA. Prof. Kato's team found out how much influenza viruses depend on the activity of this enzyme for their replication and ...

One viral protein, called the nucleocapsid protein (N), is particularly important for rapid and efficient replication. It wraps around the RNA genome in the virus and ensures that the very long ...

How skin cancer virus outcompetes DNA replication in host cells: Study(Shutterstock) The work, which was published today in the journal PNAS, gives insight on the fundamental topic of how viruses ...

Known as licensed DNA replication, this controlled process occurs only once each time a cell divides. In contrast, when a virus hijacks a host cell's DNA replication machinery, it replicates ...

2023). Their results indicate that this domain – while necessary for replication of the virus – is not a protease, but rather a structural organization and localization domain. Moreover, they also ...

However, if there is RNA in the cell that lacks the cap structure ... activity of MTr1 is thus essential for the replication of the influenza virus in the cell. The researchers want to harness ...

Virus particles that are either too small or too large, compared to the optimum, will have a much higher energetic barrier to replication, and thus will take much longer to replicate. In some ...