Moreover, the plasma angiotensinogen concentration was higher in subjects ... Subjects for whom the cause of hypertension was known and those with reduced renal function with a serum creatinine level ...

In April 2025, Actelion announced a study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the ...

Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen. Circ. Res. 94(6), 843–849 (2004).

While the exact etiology is not fully understood, emerging evidence suggests that enhanced inflammatory and oxidative stress processes during aging can dramatically decrease cognitive function in ...

Activation of the sympathetic nervous system during cold exposure is consistent with the thermoregulatory response in which sympathetically mediated vasoconstriction in the skin shunts blood from the ...

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa Department of Integrative Biomedical Sciences, University of Cape Town, Observatory 7925 ...

a Estimated cost, based on average wholesale price (Drug Topics Red Book, 1999), to the pharmacist for a one-month supply at the usual starting dosage.

For example, small interfering RNA (siRNA) targeting angiotensinogen, a key component of the RAS, has demonstrated significant blood pressure-lowering effects in preclinical models (68). By silencing ...

and the analysis of the consequences of kidney-specific gene knockouts on the distal nephron function. The acquired knowledge in these areas has allowed us to make a picture of the complex coordinated ...