AIs can outperform humans easily on short tasks, but longer ones are the true hurdle to overcome before we can deem them to be truly intelligent systems.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...

“Mechanistically, G2 cell cycle exit occurs by premature activation of the anaphase-promoting complex or cyclosome (APC/C) in G2,” they wrote. “Notably, we found that premature APC/C ...

The study, published in the journal Nature Structural and Molecular Biology, delves into the movements of the Anaphase-Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that drives the cell ...

The study, published in the journal Nature Structural & Molecular Biology, delves into the movements of the Anaphase-Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that drives the cell cycle.

Find more information on the Altmetric Attention Score and how the score is calculated. The anaphase-promoting complex/cyclosome (APC/C) coordinates advancement through mitosis via temporally ...

Specifically, the conjugation of Ub to target proteins by Ub ligases, such as the Anaphase-Promoting Complex/Cyclosome (APC/C), is paramount for cell cycle transitions as it leads to the irreversible ...

Anaphase-Promoting Complex/Cyclosome (APC/C), in this process. The APC/C is a multi-subunit complex that targets proteins for degradation via proteasome 26S. The functional characterization of APC/C ...

The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin for ...

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G 1 phase of ...