To develop a covalent modifier for the amyloid-forming protein β-2-microglobulin (magenta), researchers used a nanobody (teal ...

Discover what glycan analysis can reveal about protein behavior and how it can be used to boost biologic performance and ...

To assess the effects of n-3 polyunsaturated fatty acids (also known as omega-3 fatty acids) versus a comparator (e.g. placebo, antidepressant treatment, standard care, no treatment, wait-list control ...

More than half of proteins in prokaryotes and eukaryotes undergo N-terminal methionine excision (NME). While it is known that the penultimate amino acid affects the efficiency of NME in several ...

Summary Among the diverse methods for protein analysis, N-terminal sequencing stands out as a powerful tool for determining the amino acid sequence of proteins and peptides. This article delves into ...

In this study, we aimed to better understand the roles of several conserved amino acid residues, including Thr7 and Ser84, in the N-terminal domain. We investigated the effects of mutagenesis on ...

The N-terminal CSPs are more widespread than would be predicted for amino acid changes in an IDR, suggesting that the mutant N-terminus experiences a different chemical environment to the wild-type.

Citation: Kraujalis T, Gudaitis L, Kraujaliene L, Snipas M, Palacios-Prado N and Verselis VK (2022) The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular ...

The Y145Stop mutant of human prion protein (huPrP23-144) is associated with a familial prionopathy and provides a convenient in vitro model for investigating amyloid strains and cross-seeding barriers ...

Finally, expanded phylogenetic analysis reveals unifying connections between β-lactam synthesis and allied C domains associated with the appearance of ᴅ-amino acid and dehydroamino acid residues in ...

The N terminus is defined as the beginning of the protein chain where the amino group of the first amino acid building block is available to react. Specifically targeting the N terminus is useful ...