Amiloride achieved similar blood pressure control without the hormonal side effects linked to spironolactone, supporting its use as an alternative treatment option for resistant hypertension.

Amiloride is noninferior to spironolactone in lowering home systolic blood pressure over 12 weeks in patients with resistant hypertension. The finding is from the SPironolactone Versus Amiloride ...

Amiloride, a potassium-sparing diuretic, was noninferior to spironolactone in reducing home-measured systolic blood pressure (BP) after 12 weeks of treatment in patients with true resistant ...

At 12 weeks, mean home SBP decreased by 13.6 mm Hg in the amiloride group and 14.7 mm Hg in the spironolactone group, a noninferior difference within the trial's prespecified margin (−4.4 mm Hg ...

Noninferiority trial favored amiloride as an alternative to spironolactone in lowering home systolic blood pressure (SBP) for people with resistant hypertension. Twelve weeks into the trial ...

Background: Canada has historically been among the world leaders in hypertension care, but hypertension treatment and control ...

Adding zilebesiran to a thiazide diuretic or calcium channel blocker may lead to further blood pressure reduction in patients with uncontrolled hypertension. Zilebesiran added to hypertension ...

Objectives: To assess the efficacy and tolerability of valsartan and valsartan plus hydrochlorothiazide (HCTZ), given alone or as part of a combination regimen with other antihypertensive agents ...

Home-measured systolic blood pressure (SBP) was similarly reduced at 12 weeks among people randomized to amiloride versus spironolactone (-13.6 vs -14.7 mmHg), with amiloride meeting criteria for ...

Here we hypothesized that the deletion of plasminogen and amiloride treatment protect against hypertension in diabetes mellitus. Impaired renal sodium excretion by plasmin–epithelial sodium channel ...

Amiloride is noninferior to spironolactone in lowering home-measured systolic blood pressure (SBP) among patients with resistant hypertension, according to results from a clinical trial published May ...