New research from the MIROCALS (Modifying Immune Responses and Outcomes in ALS ... who had lower levels of cerebrospinal fluid (CSF) phosphorylated neurofilament heavy chain protein (pNFH), a ...

A doctor may consider ALS as a possible cause if a person has symptoms and physical examination findings with features of both upper and lower motor neuron disease. There is no cure for ALS ...

ALS (also known as motor neuron disease or MND) affects around 45,000 people in Europe at any one time. It attacks the nerves that control movement (motor nerves) so muscles no longer work.

Mice in this line, called TAR4, develop ALS-related phenotypes, including severe motor impairment, loss of upper and lower motor neurons, and premature death. Homozygous mice (referred to as TAR4/4) ...

1 Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia Lower motor neuron (LMN ... cause phenotypes that have been labelled dHMN, amyotrophic ...

A major clinical trial has found that low-dose interleukin-2 (IL2LD) is safe and may significantly extend survival in people with motor neurone ... ALS revealed a statistically significant survival ...

Generally, ALS is categorized in one of two ways: Upper motor neuron disease affects nerves in the brain, while lower motor neuron disease affects nerves coming from the spinal cord or brainstem. In ...

Amyotrophic lateral sclerosis (ALS) is characterised by progressive muscle weakness and degeneration of upper and lower motor neurones. The risk of developing ALS is partly genetic and partly ...