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AHA/ASA Journals4d
High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation Through Central Fibroblast Growth Factor Receptor Signaling
BACKGROUND: Recent studies have highlighted the deleterious role of high phosphate intake in hypertension by means of ...
C&EN7d
Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression
In parallel, exposure to naringin enhanced translocation of estrogen receptor alpha (ERα) to nuclei and its transactivation activity. Sequentially, naringin induced alkaline phosphatase (ALP) mRNA and ...
ahajournals.org10d
Diminished beta-adrenergic receptor responsiveness and cardiac dilation in hearts of myopathic Syrian hamsters (BIO 53.58) are associated with a functional abnormality of the G ...
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Pfizer's Oral Obesity Drug Flop - A Symptom Of A Deeper Pipeline Problem
Pfizer halted its oral obesity drug, danuglipron, in April 2025 due to liver injury concerns, a major pipeline setback. Find ...
Medscape23d
The Use of Beta-Adrenergic Receptor Antagonists in the Treatment of African Americans With Heart Failure
Major beta blocker mortality trials in chronic heart failure: a critical review. Heart. 1999;82(suppl 4):IV14 IV22. Altered adrenergic receptor sensitivity due to polymorphic variation.
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Estrogen-related receptors could be key to treating metabolic and muscular disorders
Fan and his colleagues deleted three different forms of the receptors (alpha, beta, and gamma) in the muscle tissues of mice and examined the resulting effects. They found that while the most ...