Perspective from These results highlight the role the ALK pathway plays in these rare diseases. Patients with ALK-driven anaplastic large cell lymphoma and inflammatory myofibroblastic tumors have ...

A phase 2 trial found that adding bevacizumab to alectinib significantly delayed disease progression, protected against brain ...

It is challenging to balance physician autonomy with rigid clinical pathways when it comes to these institutional decisions, which often are made by a small group. The management of ALK-positive ...

If validated, the use of anaplastic lymphoma kinase (ALK) inhibitors may be a new treatment ... and animal models to evaluate protein-signaling pathways and genetic abnormalities with the goal ...

REQORSA has a multimodal mechanism of action whereby it interrupts cell signaling pathways that cause replication and proliferation of cancer cells, such as the ALK pathway, re-establishes ...

Moreover, pharmacological or genetic inhibition of the ALK-STING pathway confers protection against lethal endotoxemia and sepsis in mice. The ALK pathway is up-regulated in patients with sepsis.

About 3-5 percent of those patients are thought to have ALK gene rearrangements and have been shown to respond to therapies that block the ALK pathway. The Vysis ALK Break Apart FISH probe kit ...