Macrophages are implicated in the pathogenesis of obesity, yet the underlying mechanisms remain incompletely understood. Here ...

Sesame seeds and sesame oil are rich in bioactive lignans, tocopherols, and unsaturated fatty acids that exert antioxidant, ...

Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protective effects of adiponectin treatment on endothelial cells and its ...

Adiponectin targets the vascular endothelium, eliciting organ-protective functions through binding to T-cadherin. The reduced obesity-induced adiponectin binding of T-cadherin reduces endothelial EV ...

Objectives: This present study aimed to examine the effects of adiponectin-transfected endothelial progenitor cells (LV-APN-EPCs) on cerebral ischemia–reperfusion injury in rats with type 2 diabetes ...

In endothelial cells, adiponectin enhances production of nitric oxide, suppresses production of reactive oxygen species, and protects cells from inflammation that results from exposure to high ...

Methods and Results— Immunohistochemical study and quantitative RT-PCR demonstrated that globular adiponectin suppressed the TNF-α–induced ICAM-1 expression in a dose-dependent manner in mouse aorta ...

Objective— Angiotensin II (Ang II) and tumor necrosis factor (TNF)-α levels increase endothelial permeability, and we hypothesized that adiponectin suppressed these responses in a cAMP-dependent ...

Adiponectin inhibited the tumor necrosis factor-α–stimulated EL secretion from cultured human coronary endothelial cells in a dose-dependent manner. Experimental low-dose endotoxemia in 20 subjects ...

Adiponectin exerts its beneficial effects through membrane-bound receptors and adaptor molecules in endothelial cells. Adiponectin increases the stability of eNOS mRNA and half-life, enhances the ...