Second, microtubule diversity is also generated by an extensive array of reversible post-translational modifications 2, such as acetylation, polyglycylation and polyglutamylation, tyrosination ...

Post-translational modifications (PTMs)—the chemical changes that proteins undergo following biosynthesis—account for most protein forms, or proteoforms. Indeed, according to conservative ...

Post-translational modifications (PTMs) are essential players in regulating protein functions, including stability, localization, and interactions, and they ...

PCAF acetylates RAD51, leading to RAD51 dissociation from chromatin and degradation. This highlights a regulatory role for ...

Ramazi S and Zahiri J. Post-translational modifications in proteins: resources, tools and prediction. Database , Volume 2021, 2021, baab012. doi: 10.1093/database/baab012 ...

Dr. Edward Arnold, a graduate student in the Avgousti lab, led critical studies to define the purpose of these modifications in adenoviral replication. To start, the group created adenoviruses with ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

What’s left is subject to a dizzying array of post-translational modifications. Phosphorylation is the best-known, and a vast literature spanning more than 30 years has tied hyperphosphorylated forms ...

By Vijay Kumar Malesu These modifications increase chromatin accessibility, influencing growth, differentiation, and ion ...