While Rheb mutations also result in mTOR pathway hyperactivation, TSC is predominately caused by mutations in the TSC2 or TSC2 genes, which are key regulators of the mTOR pathway. So, PTI-125’s ...

The company already released some positive data from the phase 1 ALLOHA study using TCR-T TSC-100/TSC-101 for these patients at the 66th American Society of Hematology [ASH] Meeting and Exposition ...

TSC held a President's Luncheon on campus at noon Monday to unveil the almanac. With this year’s theme being “African Americans in the Workforce,” the college honored local Black leaders who ...

TSC CEO Nancy Macharia described Nzioka as undoubtedly one of Kenya's most respected academic stalwarts. Till his demise, the Kepsha boss was the headteacher of Donholm Primary and Junior ...

Mechanistically, recombinant human S100A9 protein was found to induce a decrease in intracellular Ca 2+ concentration, while AT-1 regulated the expression of tight junction proteins via modulation of ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

The elevation of SCFAs, especially propionic acid, may activate the AMPK/mTOR pathway, leading to a decrease in the levels of TNF-α, IL-1β, IL-6, NF-κB, and IL-17A, while increasing the levels of ...

Kimilili MP Didmus Barasa has proposed an amendment to the Teachers Service Commission (TSC) Act, 2012. In a statement on February 24, 2025, Barasa stated that the proposed amendment aims to enhance ...