The opposite effect was observed in cells that were deficient for the tuberous sclerosis complex (TSC; an endogenous negative regulator of mTOR activity), in which mTOR is hyperactive: Tsc2 − ...
While Rheb mutations also result in mTOR pathway hyperactivation, TSC is predominately caused by mutations in the TSC2 or TSC2 genes, which are key regulators of the mTOR pathway. So, PTI-125’s ...
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