Deletions of both ABL's SH3 domain and the carboxy-terminal proline-rich SH3-binding sites (ABL-PP), but not single mutations of each, block the ability of BCR–ABL to stimulate spontaneous cell ...

Here we describe seven mutations in the SH3-binding protein SH3BP2 (MIM 602104) on chromosome 4p16.3 that cause cherubism. Nature Genetics - Mutations in the gene encoding c-Abl-binding protein ...

The classic BCR-ABL gene of CML results from the fusion of parts of two ... Van Etten, RA. Autoinhibition of Bcr-Abl through its SH3 domain. Mol Cell 2003;12:27-37. Crossref. PubMed. Web of Science.

Amplification of the BCR-ABL gene leading to overproduction of the TK can confer relative ... KM, Yacobi, R, Van Etten, RA. Autoinhibition of Bcr-Abl through its SH3 domain. Mol Cell 2003;12:27-37.

The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target ...

Paris and Strasbourg, France, June 9, 2022 - Coave Therapeutics (‘Coave’), a clinical-stage biotechnology company focused on developing life-changing gene therapies for CNS (Central Nervous System) ...

ABL1, a human gene well-known for its association with cancer now has been linked to a developmental disorder. The study, which was carried out by a team of researchers from institutions around ...

For example, some people with chronic myeloid leukemia (CML) have a change to a gene called BCR-ABL that makes their body produce the tyrosine kinase protein. This protein helps their cancer grow.