Exploring gene-drug associations is a key step in identifying new drug candidates, but traditional experimental methods are often expensive and time-consuming. While Graph Neural Network (GNN)-based ...

Our findings establish FOXK2 as a novel pathogenic gene in congenital myopathy associated with ptosis, highlighting its previously unrecognized role in skeletal muscle development. These results ...

In addition, we show that the C-terminal SH3 domain binding to a polyproline region N-terminal to the DH domain of the Tim subgroup of Dbl-family proteins provides a unique mechanism of regulated ...