A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Adipose tissue is an underappreciated and misunderstood organ. Capable of more than doubling in mass and then returning to baseline, 1 white adipose tissue (WAT) continues to play an essential ...

The rapid accrual of knowledge in genomic medicine has prompted the reanalysis of existing data. 1,2 We clinically reanalyzed data from two patient series that had undergone diagnostic proband ...

The analysis population consisted of 2536 patients (1270 in the edoxaban group and 1266 in the placebo group). The mean age was 78 years, 37.4% were women, and the median duration of AHREs was 2.8 ...

We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling.

Phenotypes Acute hepatic necrosis, serum enzyme elevations, sinusoidal obstruction, acute fatty liver, nodular regeneration Acute hepatocellular hepatitis, mixed or cholestatic hepatitis, bland ...

Diabetes control improved from 1999 to the early 2010s among the participants but subsequently stalled and declined. Between the 2007–2010 period and the 2015–2018 period, the percentage of ...

Pulmonary hypertension is a syndrome characterized by marked remodeling of the pulmonary vasculature and a progressive rise in the pulmonary vascular load, leading to hypertrophy and remodeling of ...

Currently licensed and approved malaria subunit vaccines provide modest, short-lived protection against malaria. Immunization with live-attenuated Plasmodium falciparum malaria parasites is an ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU).