The effects of obesity on cancer treatment efficacy remain unclear, as both beneficial and detrimental modulations of the tumor immune microenvironment have been reported. We compared 68Ga-NOTA-GZP ...

The value of nuclear medicine imaging for diagnosing infections, was first recognized nearly 50 y ago (1). The 3-phase bone scan was for many years the radionuclide test of choice for musculoskeletal ...

Rheumatoid arthritis (RA) affects 0.5%–1% of the global population, making it the most common inflammatory arthropathy worldwide (1). It is a complex autoimmune disease characterized by chronic ...

Treatment of non–small cell lung cancer (NSCLC) has advanced considerably over the past 40 y. In addition to the advent of molecularly targeted therapies, inhibition of immune checkpoints using ...

An essential prerequisite for a successful sentinel lymph node biopsy (SLNB) procedure is an accurate map of the pattern of lymphatic drainage from the primary tumor site in each patient. In melanoma ...

Most well-differentiated neuroendocrine tumors (NETs) express high levels of somatostatin receptors, particularly subtypes 2 and 5. Somatostatin analogs (SSAs) bind to somatostatin receptors and are ...

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Journal of Nuclear Medicine May 2025, jnumed.125.269859; DOI: https://doi.org/10.2967/jnumed.125.269859 The introduction of total-body PET, or long–axial-field-of ...

Journal of Nuclear Medicine May 2025, jnumed.125.269614; DOI: https://doi.org/10.2967/jnumed.125.269614 ...

Introduction: MNPR-101 is a humanized monoclonal antibody to the urokinase plasminogen activator receptor (uPAR). uPAR expression is elevated in several aggressive cancers but rarely if at all ...

The expanding field of theranostics combines the use of both diagnostic and therapeutic drugs that target shared molecular markers of disease. The diagnostic component of a theranostic drug pair is ...

Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high–therapeutic-index (TI) tumor ...