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1Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts. 2Massachusetts Eye and Ear, Boston, Massachusetts.

A single dose of the human papillomavirus vaccine confers protective immunity against infection on par with two doses, according to results from the NCI’s ESCUDDO trial, potentially making it easier ...

1Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon. 2Division of Hematology/Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon. ...

Major Finding: Iron activation within the lysosome triggers oxidative membrane lipid degradation and ferroptosis. Concept: Fentomycin-1 induces phospholipid oxidation and ferroptosis in cancer cells ...

Genentech will collaborate with Orionis Biosciences to discover and develop molecular glues for cancer, the companies announced today. Molecular glues are small molecules that bind to, and promote ...

Abstract. PE-0260 is a potent and selective oral methylthioadenosine (MTA)-cooperative protein arginine methyltransferase 5 (PRMT5) inhibitor leveraging the synthetic lethal relationship of PRMT5 with ...

Cancer Res (2024) 84 (6_Supplement): 4574. Conclusion: This is the first study demonstrating that nuclear export blocker KPT8602 can synergize with KRAS G12D inhibitor MRTX1133 and has the potential ...

Cancer Res (2024) 84 (6_Supplement): 2583. Introduction & Purpose: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. To date, the imaging of HCC is difficult, insufficient for ...

Bristol Myers Squibb (Princeton, NJ), Princeton, NJ.

Researchers found a treatable mechanism behind the cognitive problems that can follow CAR T-cell therapy, tracing them to overactive immune cells in the brain’s white matter. In mouse models, ...