A single base change can create a devastating genetic disorder or a beneficial ... in a frameshift Cystic fibrosis Chromosomal mutation Inversion One region of a chromosome is flipped and ...

Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression ...

However, characterizing chromosomal rearrangements with commonly tried DNA sequencing methods has been difficult. Many organisms, including humans, are diploid, meaning they have two sets of ...