The mTOR kinase domain structure starts before the FRB domain, with the long kα1 helix (‘k’ denoting kinase domain) that is present in PI3Ks as well (Fig. 2a and Supplementary Fig. 2a).The ...

Solution structure of the mTOR FRB domain. Despite a limiting solubility of about 150 μ M nearly complete 15 N-, 13 C- and 1 H-resonance assignments were obtained for the FRB domain (Veverka et ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

The mechanistic target of rapamycin, mTOR, is a downstream effector of many signaling pathways critical to human health. The 2017 Lasker Award for Basic Medical Research recognizes its discovery.

The mTOR enzyme is activated by a protein called RHEB and inhibited by one called PRAS40. The structure newly obtained by cryo-EM shows how all these pieces fit together, including how the mTOR enzyme ...

The mTOR pathway is probably the main pathway in humans and other animals that drives growth. That is, the accumulation of mass and adding mass to make an organism bigger by both making more cells ...

mTOR stands for mammalian/mechanistic target of rapamycin. Rapamycin is an immunosuppressant drug that was first isolated from a bacterium found on Easter Island in the mid-20th Century.

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes awry. Scientists ...

Overactive mTOR Plays a Key Role in Aging and Alzheimer’s Disease.Simufilam Suppresses Overactive mTOR, Suggesting a Beneficial Drug Effect.Research is Published in Frontiers in Aging, a Peer ...

QIMR Berghofer-led research in collaboration with Australian oncology company Kazia Therapeutics has found that combining the drug candidate paxalisib with immunotherapy triggered a molecular ...