Learning more about the mTOR complex and how it works is a stepping stone for others who might look for cancer therapies or ways to help treat diabetes and other diseases. In the world of biology ...

as the interactions of all the proteins in the complex are critical for its function", explains Maier. "The whole is much more than the sum of its parts." The finely tuned regulation of mTOR ...

Rapamycin specifically inhibits mechanistic TOR (mTOR) within mTOR complex 1 (mTORC1). Since their groundbreaking discovery, the TOR proteins, which have orthologues in all four eukaryotic ...

One explanation is trivial: the higher the doses, the stronger inhibition of mTOR. There is another explanation: mTOR complex 1 (mTORC1) has different affinity for its substrates. For example, ...

mTOR activity in the cell is carried out by two distinct complexes. mTORC1 complex is made up of mTOR, raptor, mLST8, and PRAS40. It is very sensitive to rapamycin and activates S6K and inactivates 4E ...

Everolimus and temsirolimus (bottom) inhibit the mechanistic target of rapamycin (mTOR) complex 1, leading to several downstream antineoplastic effects. Drug options are listed alphabetically.

as the interactions of all the proteins in the complex are critical for its function," explains Maier. "The whole is much more than the sum of its parts." The finely tuned regulation of mTOR ...

The team is working to better understand the role and functionality of the complex, named the mechanistic target of rapamycin - or mTOR for short. Learning more about mTOR and how it works is a ...

Through a collaborative effort scientists from the ETH Zürich and from the Biozentrum of the University of Basel have now succeeded in revealing the unique architecture of the mammalian TOR complex 1 ...