Although the mechanism of action of pregabalin has not been fully elucidated, some results related to pregabalin (such as gabapentin ... 30–60mL/min): reduce dose (see full labeling); (CrCl ...

The use of gabapentinoids -- gabapentin and pregabalin (Lyrica) -- has climbed in the U.S. since the drugs were first approved. Common side effects of gabapentin include somnolence, dizziness ...

Unlike gabapentin, pregabalin exhibits linear pharmocokinetics after oral administration, with low intersubject variability. [8,22,29] This provides a more predictable dose- response relationship ...