the structure of ‘stabilized plasmid-lipid particles’ (splp) and their properties as systemic gene therapy vectors has been investigated. we show that splp can be visualized employing cryo ...

Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore ...

The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the ...

Their structure makes them highly suitable ... Image Credit: InProcess-LSP Lipid-based Nano Particles form a very useful class of delivery systems in the pharmaceutical area as well as in ...

Related: Protein-lipid particles to deliver genetic medicine ... Those ionizable lipids, which are remarkably similar in structure, were discovered while the firms were optimizing LNPs for ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues. A team led by ...

The neutral/structure lipids, such as DSPC and cholesterol provide the general framework or structure of the particles, whereas pegylated lipids coat the surface of the LNPs and provide physical ...

The difference between these lipids is in how they are structured. The structure of saturated and ... high levels of LDL in your bloodstream, fat particles will attach to the walls of your ...

"The structure of the antibody itself holds an encoding principle to recognize lipids, which is something that was underappreciated before," Maillie says. Understanding these structural ...

A team led by scientists at the University of Nottingham's School of Pharmacy demonstrated a new cryogenic mass spectrometry approach for depth profiling frozen tiny lipid nanoparticles to reveal the ...